Decoding the Hidden Language of Proteins!
New study published in Science reveals that protein sequences contain hidden codes that guide them to specific subcellular compartments, ensuring precise organization within cells. With ~10 billion protein molecules needing to be correctly distributed, this discovery reshapes our understanding of protein localization!
🚀 Key Highlights:
🔹 Proteins with shared functions share common amino acid sequence codes that direct them to the same compartments.
🔹 ProtGPS, a protein language model, was developed to accurately predict protein compartment localization.
🔹 ProtGPS was used to design novel proteins that selectively assemble in the nucleolus.
🔹 The model identified disease-causing mutations that alter these compartmentalization codes, potentially leading to pathological mislocalization.
🧩 Beyond the Folding Code: This study suggests that protein sequences not only encode folding information but also contain a hidden localization code, governing their precise subcellular distribution.
📖 Read more: Science
