SciFocus/Jan 4, 2024 — A groundbreaking nano-formulation of melatonin, the hormone linked to darkness and sleep, is offering new hope for Parkinson’s disease (PD). Researchers at the Institute of Nano Science and Technology (INST), Mohali, have demonstrated its enhanced neuroprotective and antioxidative properties, marking a step forward in the fight against this debilitating neurological disorder.
“nano-melatonin formulation enhances therapeutic efficacy by targeting the brain with improved bioavailability and sustained release.”
Key Highlights
- Parkinson’s Disease Background:
- Affects millions worldwide, caused by the death of dopamine-secreting neurons.
- Current treatments only manage symptoms, with no cure available.
- Role of Melatonin:
- Naturally produced in the brain, it regulates the sleep-wake cycle.
- Acts as an antioxidant and potential inducer of mitophagy (removal of dysfunctional mitochondria).
- Nano-Formulation Advances:
- Delivery Mechanism: Human Serum Albumin (HSA) nano-carrier ensures targeted brain delivery.
- Improved Efficacy:
- Sustained release of melatonin enhances bioavailability.
- Reduced oxidative stress through mitophagy induction.
- Boosts mitochondrial biogenesis to counteract rotenone toxicity (a PD model toxin).
- Epigenetic Regulation:
- The nano-formulation upregulates BMI1, an epigenetic regulator critical for gene expression and mitophagy.
- This helps protect neurons and alleviates PD symptoms.
- Preclinical Validation:
- Studies in rat models showed significant neuroprotection.
- Highlighted in vitro and in vivo benefits in the prestigious journal ACS Applied Materials & Interfaces.
Potential Impact
This innovative approach offers hope for:
- Establishing melatonin as a therapeutic candidate for Parkinson’s.
- Extending treatment options to other conditions linked to mitochondrial dysfunction.
- Providing a safer, more effective neurotherapeutic solution.
For further details, read the official press release: PIB Press Release.
This breakthrough reinforces the importance of nanotechnology in revolutionizing healthcare and promises brighter prospects for those battling Parkinson’s disease.
