Linking miRNA export to Extracellular Vesicles – A paradigm change in the understanding of cancer epigenetics

Souvik Ghosh, Kamalika Mukherjee and Yogaditya Chakrabarty joint first author interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Here, authors talk about their work titled “GW182 Proteins Restrict Extracellular Vesicle-Mediated Export of miRNAs In Mammalian Cancer Cells” published in Molecular and Cellular Biology (2021).

Biomimetic microvasculature-on-a-chip for drug screening applications

Jyotsana Priyadarshani’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Jyotsana completed her B.Tech. and M.E. both in Biomedical Engineering from JIS college of Engineering, WBUT and Jadavpur University (JU) respectively. She worked with Prof. Himadri Chattopadhyay, JU for her M.E. thesis in hemorheology. Currently, she is pursuing her PhD in the area of “organ-on-a-chip” under the supervision of Prof Soumen Das & Prof Suman Chakraborty at SMST, IIT Kharagpur. Her research focuses on utilizing the frugal fabrication technique and microfluidic applications to address the important features and geometrical complexities of microvasculature in vitro. Such bioengineered microfluidic platforms are potentially suitable for probing cellular dynamics as well as offering critical insights into cancer, cardiovascular diseases, offsetting the requirements of in vivo trials on animals and humans to a large extent. Here, Jyotsana talks about her work titled “Transport of vascular endothelial growth factor dictates on-chip angiogenesis in tumor microenvironment” published as the first author in Physics of Fluids journal.

RNA-based biosensors win a race for metabolite-sensing in cells

Dr. Sudeshna Manna’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Manna is currently a postdoctoral scholar at the group of Prof. Ming Hammond in the University of Utah, USA, where she works on RNA engineering to develop genetically encodable tools for synthetic biology, cell biology, and biotechnology applications. She pursued her Ph.D. in 2019 in the Indian Institute of Science Education and Research (IISER) Pune, India, under the supervision of Prof. S. G. Srivatsan. Her Ph.D. was focused on the chemical biology of nucleic acids, particularly on the development of nucleoside probes to understand the structure and recognition of nucleic acids in the cell-free and cellular environment. Before joining her Ph.D., she obtained her master’s and bachelor’s degrees in chemistry from the Indian Institute of Technology (IIT) Guwahati and Jadavpur University, Kolkata, India, respectively. Her research interest revolves around synthetic biology, nucleic acids, and protein-based tools for diagnostics and therapeutics and exploring new antimicrobial targets. Here, Sudeshna talks about her first author work on “Guanidine Biosensors Enable Comparison of Cellular Turn-on Kinetics of Riboswitch-Based Biosensor and Reporter” published in ACS Synthetic Biology (2021).

Raman spectroscopy- an emerging analytical technique in biopharmaceuticals

Nitika’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Nitika is a Ph.D. scholar in the Chemical engineering department of IIT-Delhi. Her research interest lies in the continuous downstream processing of therapeutic proteins and analytical techniques to detect critical quality attributes of the process. Nitika has done her B.Tech. in Biotechnology (2012-2016) from University School of Biotechnology, Guru Gobind Singh Indraprastha University, New Delhi. After which, she did her M.S. (Research) from the Department of Biochemical Engineering and Biotechnology, IIT Delhi, during 2016-2018. In 2018 she joined IIT-Delhi’s Chemical Engineering Department for Ph.D. under the guidance of Prof. Anurag S. Rathore. She cleared GATE (Biotechnology) in 2016 with AIR 37, DBT-JRF (2018), CSIR-JRF (June 2018 and Dec 2018). Here, Nitika talks about her work titled ”Raman spectroscopy for in situ, real time monitoring of protein aggregation in lyophilized biotherapeutic products” published as the first author in International Journal of Biological Macromolecules (2021).

Job opening in Lambdagen Therapeutics

We are seeking an experienced Research Scientist to develop chimeric antigen receptor (CAR) Natural Killer cell-based cancer immunotherapies using proprietary lambda-integrase genome engineering technology. The ideal candidate will assist in the design of targeted iPSC-derived NK cell therapies, provide subject matter expertise for the development of allogeneic cell therapies targeting hematopoietic malignancies, and guide the evaluation of candidate cellular therapies from POC through pre-clinical studies.