Impact of mAb Aggregation on its Biological Activity

Dr. Rozaleen Dash’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Dash completed her PhD in Biochemistry from All India Institute of Medical Sciences, New Delhi then, she joined as Scientist- B at Maulana Azad Medical College, New Delhi. Currently, she is doing Post-Doc as a ICMR-RA fellow in the Professor Anurag S Rathore Lab, Department of Chemical Engineering, Indian Institute of Technology Delhi, India. She has expertise in Functional Characterization of biotherapeutics, Comparability of Biosimilars and Drug immunogenicity. Here, she talks about her co-first author research article titled “Impact of mAb Aggregation on Its Biological Activity: Rituximab as a Case Study” published in the Journal of Pharmaceutical Sciences (2020).

Withaferin A as a potent regulator of hepatocellular carcinoma

Varsha D. Shiragannavar’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Varsha is currently a second year Ph.D. student working in the lab of Dr. Prasanna K. Santhekadur at Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory, Department of Biochemistry, JSS Medical College, JSS AHER, Mysuru. Her doctoral studies is primarily focused on investigating the role of RNA-induced silencing complex and associated proteins in the progression of non-alcoholic fatty liver disease and hepatocellular carcinoma. She is trying to understand the molecular/cellular process on how RISC complex genes and protein are regulated when treated with many dietary natural products. Here, Varsha talks about her work titled “Withaferin A Acts as a Novel Regulator of Liver X Receptor-a in HCC” published as first author in Front Oncol 2021.

Time-restricted feeding prevents breast cancer

Dr. Manasi Das did her Master in Life Sciences from Sambalpur University, Odisha, India. After that, she did her Ph.D. from the Institute of Life Sciences, Bhubaneswar, Odisha, India, under the supervision of Dr. Sanjeeb Kumar Sahoo, where she studied on Nanodrug delivery for breast cancer therapy. Presently, she is Postdoctoral Fellow in the Department of Medicine, University of California, San Diego, USA. Her research focuses on understanding the role of time-restricted feeding/eating intervention in breast cancer. Here, Manasi and Deepak talks about their work titled “Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models” published in Nature communications.

Bio Patrika interviews Dr. Kasoju on his thoughts about “Tissue engineering using novel cell culture inserts”

Dr. Naresh Kasoju’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Kasoju is a Scientist in Applied Biology from Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (An Institute of National Importance, Dept. of Science and Technology, Govt. of India), Thiruvananthapuram, India. Earlier, he obtained Ph.D.Continue reading “Bio Patrika interviews Dr. Kasoju on his thoughts about “Tissue engineering using novel cell culture inserts””

Bio Patrika interviews Mr. Chameettachal on his thoughts about “application of Biomimetic Hydrogel for Corneal Tissue Regeneration”

Mr. Shibu Chameettachal’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Shibu has started his career as a microbiologist and selected Tissue engineering as his area of research. He has gained research experience at the Indian Institute of Technology Delhi before joining PhD. He is currently a PhD scholar at the Department of Biomedical Engineering, Indian Institute of Technology Hyderabad. His research interest is in 3D bioprinting of tissue and organ development and currently working on corneal regeneration. He is a recipient of the prestigious Biotechnology Industry Research Assistance Council-Gandhian Young Technological Innovation Award in 2018. Shibu has a good publication record, including reviews and book chapters. He presented his research work at national and international conferences. Here Shibu talks about his first author publication “Differentiation In Vitro Using a Biomimetic ECM Hydrogel for Corneal Tissue Regeneration” published in ACS Applied Bio Materials.

Bio Patrika interviews Dr. Das on his thoughts about “how ERK mediated phosphorylation regulate oocyte numbers”

Dr. Debabrata Das’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Das completed his Ph.D. as a DST-INSPIRE-fellow in the Cellular and Molecular Endocrinology Laboratory of Dr. Sudipta Maitra at the Department of Zoology, Visva-Bharati University, Santiniketan, India. His Ph.D. work was focused on the role of insulin-signaling pathway in regulating female reproduction using zebrafish as model organism. After his Ph.D., He joined the Arur Laboratory at the University of Texas MD Anderson Cancer Center in 2017. Currently, he is an Odyssey post-doctoral fellow. Here using C. elegans germline, he is working on the downstream substrates of RAS/ERK signaling pathway in regulating female fertility with special emphasis on meiosis I, as well as their role in cancer progression. Here, Debabrata talks about his PhD work titled “ERK phosphorylates chromosomal axis component HORMA domain protein HTP-1 to regulate oocyte numbers” published as a first author in Science Advances (2020).

Bio Patrika interviews Dr. Sethi on her thoughts about “Serial in-solution digestion protocol for mass spectrometry-based glycomics and proteomics analysis”

Dr. Manveen K Sethi’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Sethi serves as Instructor of Biochemistry at the Boston University School of Medicine, USA. She did her Ph.D. at Macquarie University (MQ), Australia, under the primary supervision of Dr. Morten Thaysen-Andersen, an internationally recognized researcher in Glycobiology. During her Ph.D., she forayed into colorectal cancer (CRC) research. After her Ph.D., she was offered a postdoctoral research fellowship at Boston University School of Medicine (BUSM), USA, under Prof. Joseph Zaia, an internationally-acclaimed leader in mass spectrometry (MS) and Glycoscience, where she is currently employed in a research faculty-track position of Instructor. Her research work involves identifying and characterizing biomolecules such as proteins and glycans using mass spectrometry techniques and utilizing this information to understand biomolecular deregulation in human diseases, such as cancer and Alzheimer’s disease. Here, Manveen talks about her work titled “Serial in-solution digestion protocol for mass spectrometry-based glycomics and proteomics analysis” published as a first author in Molecular Omics (2020).

Bio Patrika interviews Dr. Sridhar on his thoughts about “Understanding fundamental design principles of a cellular load-bearing machine”

Dr. Shreyas Sridhar’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Here, Shreyas talks about his PhD work titled “Bridgin connects the outer kinetochore to centromeric chromatin” published as first author in Nature Communications (2021).

Bio Patrika interviews Mr. Agrawal on his thoughts about “Dopamine induces functional extracellular traps in microglia”

Mr. Ishan Agrawal’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Ishan is currently doing Ph.D. in the lab of Dr. Sushmita Jha at Indian Institute of Technology Jodhpur. He is studying the role of inflammasomes and microglia in brain cancer and neuro-inflammation. In future, Ishan is interested in investigating howContinue reading “Bio Patrika interviews Mr. Agrawal on his thoughts about “Dopamine induces functional extracellular traps in microglia””

Bio Patrika interviews Dr. George on his thoughts about “the application of innovative technology sgRNA-Click combined with CRISPR-dCas9”

Dr. Jerrin Thomas George’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. George completed integrated MS-PhD from the IISER Pune. He pursued his doctoral research in the group of Prof. Seergazhi G. Srivastan on developing chemo-enzymatic platforms to functionalize RNA with biophysical probes using template dependent and independent polymerases. He then had a short stay as a research associate at JNCASR, Bangalore in the group of Dr. Sarit S. Agasti and now plans to join Columbia University, New York as a postdoctoral research scientist. His research interest is in the broad area of chemical biology, and molecular biophysics. For his future carrier, he is interested in deciphering the molecular mechanism of novel gene editing tools using various biophysical techniques. Jerrin published part of his PhD work titled “Terminal uridylyl transferase mediated site-directed access to clickable chromatin employing CRISPR-dCas9” as first author in Journal of the American Chemical Society (2020).