Restoring the Wnt/β-catenin signaling rescues bone defects in Job syndrome

Dr. Prem Swaroop Yadav was born in the Chaubeypur village of Varanasi district of Uttar Pradesh, India. He finished his schooling from the Govt. Queens Inter College (GIC), Varanasi. After completing his Bachelor’s and Master’s degrees from the Udai Pratap Autonomous College in Varanasi, he joined the PhD program at the Biological Sciences and Bioengineering (BSBE) Department, IIT Kanpur, India in 2016. He pursued his PhD under the supervision of Prof. Amitabha Bandyopadhyay. For his post-doctoral research, he moved to Boston, USA and joined the laboratory of Prof. Yingzi Yang at the Harvard School of Dental Medicine (HSDM) where he studied the pathophysiology of skeleton-related genetic disorders. Recently, he has joined Prof. Marie B. Demay’s group as a Research Fellow in Medicine at the Massachusetts General Hospital (MGH) & Harvard Medical School (HMS), Boston, USA. In Demay’s lab, he is investigating the role of key signaling pathways involved in hypertrophic differentiation of chondrocytes (which are the cartilage forming cells) and their endocrine regulation during bone development.

Scientific Zeal

Dr. Swati Priya is an ICMR Postdoctoral Researcher from National Institute of Immunology. She graduated from Miranda House (Delhi University) in Zoology(H) and post-graduated in Biomedical Science from Dr. B. R. Ambedkar Centre for Biomedical Research (Delhi University). She started her research career in 2012 when she joined for her Ph.D research work at National Institute of Immunology. She has worked extensively in the field of miRNA and Colon Cancer. She worked on the collaborative projects, where she deciphered the role of Histone activation marks in the presence and absence of Bloom Helicase and its global role in gene expression. She has also worked on project involving the role of BLM in c-Jun degradation with the help of FBW7 alpha. Her extensive work also helped in contribution towards recruitment studies of BLM on DNA double stranded break sites. Her current research work involves deciphering the DNA damage sensitive miRs upregulation in rectal cancer and their regulation and downstream target genes. Her work further elaborates and gives insight into BLM involvement in the expression of miRs via resolving G4 quadraplex present on miRS TSS in B cell lymhoma.

Not just blood cells; the blood stem cell niche can sense infection

Parvathy Ramesh is a doctoral student in the laboratory of Dr.Lolitika Mandal at Indian Institute of Science Education and Research (IISER), Mohali. She completed her integrated BS-MS dual degree from IISER, Mohali. Her PhD work mainly involves understanding what it takes to make a stem cell niche using Drosophila larval hematopoietic organ lymph gland as a model system. Here, Parvathy talks about her work “Relish plays a dynamic role in the niche to modulate Drosophila blood progenitor homeostasis in development and infection,” recently published in eLife.

Targeting heat shock response in mouse models of progressive genetic epilepsy

Author interview: Dr. Priyanka Sinha has completed her Ph.D. in neuroscience under the supervision of Prof. S. Ganesh at the department of Biological Sciences and Bioengineering, IIT Kanpur, where she studied the molecular mechanism of epilepsy using mouse models of Lafora disease. Next, she will be joining Harvard Medical School this September to study protein-protein interactions in Alzheimer disease. She is interested in studying neuron-glia interactions and their role in health and disease. In my free time, Priyanka love to read, cook, and watch television series.

Catalytic switch mediated by a bio-catalyst

Author interview: Rishi Ram Mahato belongs to a small town; Chakradharpur, West Singhbhum, in Jharkhand. He has completed his graduation degree from St. Xavier’s College, Ranchi. After which he joined Indian Institute of Technology (Indian School of Mines) Dhanbad for Post-graduation in 2017. He is currently pursuing Ph.D. at IISER Mohali under the supervision of Dr. Subhabrata Maiti. He is presently working on bio-catalytic systems. Apart from research, Rishi Ram is very keen to play cricket and badminton. He also likes to know about Indian History and Polity.

Argonaute navigating the balance between protein translation and small RNA synthesis

First author interview: Dr. Meetali Singh is currently working as a Pasteur-Roux-Cantarini Postdoctoral fellow in the Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris with Dr. Germano Cecere. She obtained her B.Sc. honors degree in Biomedical Sciences from Delhi University and then joined the Indian Institute of Science, Bangalore for the Integrated PhD program where she did her PhD in Prof. Utpal Tatu’s lab at the Department of Biochemistry. During her PhD, Dr. Singh studied the role of the chaperone Hsp90 in the life cycle and virulence of protozoan parasites and investigated the evolution of the Hsp90 complex and its function in primitive protozoa, primarily using parasites like Entamoeba, Trichomonas and Theileria as models. For her post-doc research, Meetali transitioned to explore sRNA-mediated epigenetic gene regulation and inheritance in the free-living worm, C. elegans, in the lab of Dr. Germano Cecere at Institut Pasteur, Paris. She is currently investigating the biogenesis and function of endo-siRNAs and their transmission from soma to germline by integrating proteomic, biochemical, and high-throughput genomic approaches. In her free time, she loves to read, travel and very recently picked up abstract acrylic painting as a hobby.

OmpV- A step towards vaccination against salmonellosis

First author interview: Dr. Deepinder Kaur was born and brought up in Patiala, Punjab. She did her bachelor’s in biotechnology from Khalsa College, Patiala, followed by masters in biotechnology from Thapar University, Patiala. She has completed her Ph.D. under the supervision of Dr. Arunika Mukhopadhaya, an Associate Professor in the Department of Biological Sciences, IISER Mohali. The title of her Ph.D. thesis is “Understanding the role of OmpV, an outer membrane protein of Salmonella Typhimurium towards bacterial pathogenesis and host immune activation.” Here she talks about her work “Salmonella Typhimurium adhesin OmpV activates host immunity to confer protection against systemic and gastrointestinal infection in mice” recently published in Infection and Immunity.

Building a subcellular clamp on the plasma membrane

Dr. Tushna Kapoor’s interview with Bio Patrika hosting “Vigyaan Patrika,” a series of author interviews. Tushna did her bachelor’s in Biochemistry, from Sri Venkateswara College, University of Delhi. Subsequently, she joined the Tata Institute of Fundamental Research (TIFR), in Mumbai, where she worked in the laboratory of Prof. Krishanu Ray, as an integrated Ph.D. student. Tushna’s doctoral work involves deciphering the role of the cell membrane, cytoskeleton, and cell adhesion remodeling during spermatid maturation in Drosophila. Her recent paper shows that the somatic cell plasma membrane folded around maturing spermatid heads can recruit a repertoire of proteins that assemble a membrane-cytoskeleton substructure, which clamps together the spermatid heads, and also prevents them from piercing through the somatic cell membrane. This work highlights novel roles of membrane-actin interactions, in an in vivo tissue system. Tushna is currently working at the Institute of Science and Technology (IST), Austria. Here, Tushna talks about her work ‘An actomyosin clamp assembled by the Amphiphysin-Rho1-Dia/DAAM-Rok pathway reinforces somatic cell membrane folded around spermatid heads’ published in Cell Reports

Malarial Parasites Overcome Unusual ‘hurdles’ to Synthesize Proteins

Chhaminder Kaur’s interview with Bio Patrika hosting “Vigyaan Patrika,” a series of author interviews. Chhaminder is a doctoral candidate in the Department of Biosciences and Bioengineering at the Indian Institute of Technology Bombay. She has been intrigued with biology since her school days, which led her to pursue Bachelors in Biotechnology from Netaji Subhas Institute of Technology at Delhi. Having gained subject expertise in Biotechnology, she worked as a Patent Analyst in The Smart Cube in India where she helped the clients with knowledge about prior art and the latest developments in Biotechnology. To gain a deeper understanding of the field, she joined Molecular Parasitology Lab at IIT Bombay where her research interests revolve around studying the regulation of protein synthesis in the malarial parasite, Plasmodium falciparum and another apicomplexan parasite, Toxoplasma gondii. Chhaminder has published two peer-reviewed publications papers among which one of the publications has been recognized as the “Paper of the Month” July 2020 issue of the journal Parasitology. She has presented her work in both National as well as international conferences. Here, Chhaminder talks about her work on ‘Messenger RNAs with large numbers of upstream open reading frames are translated via leaky scanning and reinitiation in the asexual stages of Plasmodium falciparum’ published in Parasitology.