Not just blood cells; the blood stem cell niche can sense infection

Parvathy Ramesh is a doctoral student in the laboratory of Dr.Lolitika Mandal at Indian Institute of Science Education and Research (IISER), Mohali. She completed her integrated BS-MS dual degree from IISER, Mohali. Her PhD work mainly involves understanding what it takes to make a stem cell niche using Drosophila larval hematopoietic organ lymph gland as a model system. Here, Parvathy talks about her work “Relish plays a dynamic role in the niche to modulate Drosophila blood progenitor homeostasis in development and infection,” recently published in eLife.

Targeting heat shock response in mouse models of progressive genetic epilepsy

Author interview: Dr. Priyanka Sinha has completed her Ph.D. in neuroscience under the supervision of Prof. S. Ganesh at the department of Biological Sciences and Bioengineering, IIT Kanpur, where she studied the molecular mechanism of epilepsy using mouse models of Lafora disease. Next, she will be joining Harvard Medical School this September to study protein-protein interactions in Alzheimer disease. She is interested in studying neuron-glia interactions and their role in health and disease. In my free time, Priyanka love to read, cook, and watch television series.

Catalytic switch mediated by a bio-catalyst

Author interview: Rishi Ram Mahato belongs to a small town; Chakradharpur, West Singhbhum, in Jharkhand. He has completed his graduation degree from St. Xavier’s College, Ranchi. After which he joined Indian Institute of Technology (Indian School of Mines) Dhanbad for Post-graduation in 2017. He is currently pursuing Ph.D. at IISER Mohali under the supervision of Dr. Subhabrata Maiti. He is presently working on bio-catalytic systems. Apart from research, Rishi Ram is very keen to play cricket and badminton. He also likes to know about Indian History and Polity.

Malarial Parasites Overcome Unusual ‘hurdles’ to Synthesize Proteins

Chhaminder Kaur’s interview with Bio Patrika hosting “Vigyaan Patrika,” a series of author interviews. Chhaminder is a doctoral candidate in the Department of Biosciences and Bioengineering at the Indian Institute of Technology Bombay. She has been intrigued with biology since her school days, which led her to pursue Bachelors in Biotechnology from Netaji Subhas Institute of Technology at Delhi. Having gained subject expertise in Biotechnology, she worked as a Patent Analyst in The Smart Cube in India where she helped the clients with knowledge about prior art and the latest developments in Biotechnology. To gain a deeper understanding of the field, she joined Molecular Parasitology Lab at IIT Bombay where her research interests revolve around studying the regulation of protein synthesis in the malarial parasite, Plasmodium falciparum and another apicomplexan parasite, Toxoplasma gondii. Chhaminder has published two peer-reviewed publications papers among which one of the publications has been recognized as the “Paper of the Month” July 2020 issue of the journal Parasitology. She has presented her work in both National as well as international conferences. Here, Chhaminder talks about her work on ‘Messenger RNAs with large numbers of upstream open reading frames are translated via leaky scanning and reinitiation in the asexual stages of Plasmodium falciparum’ published in Parasitology.

Molecular traffic and behaviour of biomolecules

Akshi Deshwal’s interview with Bio Patrika hosting “Vigyaan Patrika,” a series of author interviews. Akshi is currently pursuing Ph.D at IISER Mohali in the bio-organic field under the supervision of Dr. Subhabrata Maiti. She studies biomolecules such as liposomes and enzymes and their behavior in macromolecularly crowded media or in compartmentalized system. She finds environment sustainability applications very fascinating and plans on pursuing it further in her career.

CLASP (Continuous lifestyle awareness through sweat platform) – An on-demand sensor for lactate monitoring in sedentary populations

Ashlesha Bhide’s interview with Bio Patrika hosting “Vigyaan Patrika,” a series of author interviews. Ashlesha is currently a doctoral candidate in the Department of Bioengineering at The University of Texas at Dallas. She completed her Bachelors in Instrumentation Technology from M.S. Ramaiah Institute of Technology in Bengaluru, India, and further obtained her Master of Science degree in Electrical and Computer Engineering from the University of Manitoba in Winnipeg, Canada in 2014. Subsequently, she worked as a research assistant at the Centre for Nano Science and Engineering (CeNSE), Indian Institute of Science in Bengaluru, India till 2016 before joining Dr. Shalini Prasad’s lab at UT Dallas. Her research interests are focused on developing wearable platforms for lifestyle management. Her current research is based on developing wearable sensors for non-invasive, continuous monitoring of lifestyle biomarkers in passively expressed sweat. She currently has 13 peer-reviewed publications and has received fellowships and awards for her Ph.D. research. Recently, her latest research was featured on the back cover of RSC Analyst and has gained recognition in the sweat wearables space.

Plant cyclotides protect against β-amyloid toxicity in transgenic Caenorhabditis elegans

Neha Kalmankar’s interview with Bio Patrika hosting “Vigyaan Patrika”, a series of author interviews. Neha is a PhD student under the supervision of Dr. Radhika Venkatesan and Prof. R. Sowdhamini at the National Centre for Biological Sciences, Bengaluru. She completed her Bachelors in Engineering degree in Biotechnology at Sir. M. Visvesvaraya Institute of Technology, Bengaluru. Soon after completing herundergraduate degree, she joined Prof. P. Balaram’s lab at the Indian Institute of Science (IISc) as a JRF, exploring the computational aspects of protein sequence, structure & function. Her PhD topic includes biochemical characterization, conformational analysis and therapeutic application of plant cyclic peptides – “cyclotides”. She has worked towards isolating and sequencing cyclotides from different tissues of Clitoria ternatea using chromatographic, mass-spectrometric and transcriptomic techniques. She has further investigated the therapeutic potential of cyclotides, specifically as agents against neurodegenerative disorders. When she is not working in the lab, she enjoys travelling, exploring different cultures, cuisines and languages. She also enjoys painting and exploring creative arts in her free time. Here, Neha talks about her work on “Disulfide-rich cyclic peptides from Clitoria ternatea protect against β‑amyloid toxicity and oxidative stress in transgenic Caenorhabditis elegans” published in Journal of Medicinal Chemistry (2021).

A Talk on Nanotheranostic System for Targeted Breast Cancer Therapy developed by IISER-K

Dr. Tapan Kumar Dash and Diptendu Patra’s joint interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Tapan and Diptendu are joint-first authors on the recent research paper “Hetero-Trifunctional Malonate-Based Nanotheranostic System for Targeted Breast Cancer Therapy” published in ACS Appl Bio Mater. In this interview, they talk about this work done with Prof. Raja Shunmugam at Indian Institute of Science Education and Research Kolkata.

miRNA compartmentalisation paves a new avenue in neuroinflammatory process of Alzheimer’s Disease

Mr. Dipayan De’s interview with Bio Patrika hosting “Vigyaan Patrika”, a series of author interviews. Dipayan is from CSIR-Indian Institute of Chemical Biology, Kolkata. He started his Science journey from St. Xavier’s College, Kolkata where he undertook a bachelor’s degree in Science majoring in Microbiology and went onto do a Master’s in Biochemistry at University of Calcutta. Currently, he is pursuing his Ph.D. under the supervision of Dr. Suvendra Bhattacharyya at CSIR-Indian Institute of Chemical Biology, Kolkata. From the very beginning, his specific scientific interest in the field of small RNA was nurtured by his mentor Dr. Bhattacharyya. Under the eminent guidance of Dr. Bhattacharyya, he delved into exploring the details of how cellular organelles regulate small RNA activity in mammalian cells. One of his recent findings highlights how mTOR reactivation improves memory and disease pathology by regulating miR-146a activity in Alzheimer’s disease brain that has been published in Molecular Therapy: Nucleic Acids (De et al., 2021). He fosters a deep passion in the imaging field and would like to dig deep into the fascinating realms of microscopy in the future. When not in the laboratory, Dipayan is an ardent foodie and loves to travel. Here in this interview, Dipayan discusses his new findings “Amyloid-β oligomers block lysosomal targeting of miRNPs to prevent miRNP recycling and target repression in glial cells ” published in “Journal of Cell Science”.

SWEATSENSER Dx: A Wearable Device for Tracking Infections from Sweat

Mr. Badrinath Jagannath’s interview with Bio Patrika hosting “Vigyaan Patrika”, a series of author interviews. Badri is a doctoral candidate in the Department of Bioengineering at The University of Texas at Dallas. He completed his Bachelors in Electronics and Instrumentation Engineering in India and obtained Master of Science degree in Biomedical Engineering from Arizona State University in 2015 before joining Dr. Shalini Prasad’s lab at UT Dallas. His research interests include developing wearable and point-of-care devices for precision health. His current research focuses on developing wearable sensors for real-time monitoring of upper respiratory infections and inflammatory bowel disease non-invasively from sweat. Badri currently has 17 peer-reviewed publications among which two of the publications have been recognized as one of the Top 10 articles in Nature Scientific Reports and Inflammatory Bowel Diseases journals. He has received several awards and fellowships for his research work. Badri has given podium presentations at various conferences and has also been an invited Plenary speaker for his work on wearable diagnostics. His research work on infection monitoring wearable sensor has received a lot of recognition and was recently featured at the ACS conference 2021.