Linking miRNA export to Extracellular Vesicles – A paradigm change in the understanding of cancer epigenetics

Souvik Ghosh, Kamalika Mukherjee and Yogaditya Chakrabarty joint first author interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Here, authors talk about their work titled “GW182 Proteins Restrict Extracellular Vesicle-Mediated Export of miRNAs In Mammalian Cancer Cells” published in Molecular and Cellular Biology (2021).

Biomimetic microvasculature-on-a-chip for drug screening applications

Jyotsana Priyadarshani’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Jyotsana completed her B.Tech. and M.E. both in Biomedical Engineering from JIS college of Engineering, WBUT and Jadavpur University (JU) respectively. She worked with Prof. Himadri Chattopadhyay, JU for her M.E. thesis in hemorheology. Currently, she is pursuing her PhD in the area of “organ-on-a-chip” under the supervision of Prof Soumen Das & Prof Suman Chakraborty at SMST, IIT Kharagpur. Her research focuses on utilizing the frugal fabrication technique and microfluidic applications to address the important features and geometrical complexities of microvasculature in vitro. Such bioengineered microfluidic platforms are potentially suitable for probing cellular dynamics as well as offering critical insights into cancer, cardiovascular diseases, offsetting the requirements of in vivo trials on animals and humans to a large extent. Here, Jyotsana talks about her work titled “Transport of vascular endothelial growth factor dictates on-chip angiogenesis in tumor microenvironment” published as the first author in Physics of Fluids journal.

Raman spectroscopy- an emerging analytical technique in biopharmaceuticals

Nitika’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Nitika is a Ph.D. scholar in the Chemical engineering department of IIT-Delhi. Her research interest lies in the continuous downstream processing of therapeutic proteins and analytical techniques to detect critical quality attributes of the process. Nitika has done her B.Tech. in Biotechnology (2012-2016) from University School of Biotechnology, Guru Gobind Singh Indraprastha University, New Delhi. After which, she did her M.S. (Research) from the Department of Biochemical Engineering and Biotechnology, IIT Delhi, during 2016-2018. In 2018 she joined IIT-Delhi’s Chemical Engineering Department for Ph.D. under the guidance of Prof. Anurag S. Rathore. She cleared GATE (Biotechnology) in 2016 with AIR 37, DBT-JRF (2018), CSIR-JRF (June 2018 and Dec 2018). Here, Nitika talks about her work titled ”Raman spectroscopy for in situ, real time monitoring of protein aggregation in lyophilized biotherapeutic products” published as the first author in International Journal of Biological Macromolecules (2021).

Machine-free DNA amplification using triangular gold and silver nanoparticles

Pradeep Kadu and Satyaprakash Pandey’s joint first author interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Here, authors talk about their first author research article titled “Machine-Free Polymerase Chain Reaction with Triangular Gold and Silver Nanoparticles” published in J Phys Chem Lett (2020).

Deciphering the architecture of multiphasic biomolecular condensates

Taranpreet Kaur’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Taranpreet is currently a research assistant and working towards her Ph.D. in Dr. Priya Banerjee’s lab at the Department of Physics, SUNY Buffalo, NY. Her research focuses on biophysical methods to characterize biomolecular condensates/ Membrane-less organelles, spontaneously formed by Intrinsically disordered proteins and Nucleic Acids. She is from Ludhiana, Punjab, India, and completed her Master’s degree in Physics from Panjab University, Chandigarh. She is a confused physicist in the exciting but complex world of biology, who loves singing and dancing when she is not doing experiments. Here, Taranpreet talks about her work titled ” Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies ” published as the first author in Nature Communications (2021).

DOP-2 went to a party, got high on alcohol/dopamine and danced like a peacock

Dr. Pratima Pandey and Anuradha Singh’s joint interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Here, first authors talk about their work published in Plos Genetics.

Olfaction-immune cells metabolic cross talk and its relevance in immune responses

Miss Sukanya Madhwal’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Sukanya completed her Masters’s degree in Biotechnology from Banasthali Vidyapith, Rajasthan. After this, she served as a graduate teacher for one year at P.G. College, Kotdwara, Uttarakhand. In 2014, she qualified the JGEEBILS exam conducted by NCBS/TIFR and joined as a Research Scholar (Ph.D. student) in Dr. Tina Mukherjee’s lab at inStem. Her research has significantly contributed to uncovering key findings in Drosophila immunity. She further aspire to continue her research venture in the field of immunology. Besides work, she love reading non-fiction books, enjoy gardening and cooking delicious food. Here, Sukanya talks about her work titled “Metabolic control of cellular immune-competency by odors in Drosophila”, published as the first author in eLife, 2020.

Development of safe and easily scalable nanomedicine to deliver highly hydrophobic anti-cancer drug

Omkar Mhatre’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Mhatre completed his B.Tech from the ICT Mumbai and M.Tech from IIT Bombay. He finished M.Tech dissertation work in cancer nanomedicine under the guidance of Prof. Rohit Srivastava. Currently, he is a PhD student in the Department of Biomedical Engineering at the University of Delaware, USA. Here he talks about his first-author research article (M.Tech research work) titled “pH-responsive delivery of anti-metastatic niclosamide using mussel inspired polydopamine nanoparticles” published in the International Journal of Pharmaceutics (2021).

Post-transcriptional modification in ceramide synthase 2 enzyme leads to tumor progression in breast cancer

Trishna Pani, Kajal Rajput and Animesh Kar joint first author interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Here, authors talk about their first author research article titled “Alternative splicing of ceramide synthase 2 alters levels of specific ceramides and modulates cancer cell proliferation and migration in Luminal B breast cancer subtype” published in Cell Death Dis (2021).

Withaferin A as a potent regulator of hepatocellular carcinoma

Varsha D. Shiragannavar’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Varsha is currently a second year Ph.D. student working in the lab of Dr. Prasanna K. Santhekadur at Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory, Department of Biochemistry, JSS Medical College, JSS AHER, Mysuru. Her doctoral studies is primarily focused on investigating the role of RNA-induced silencing complex and associated proteins in the progression of non-alcoholic fatty liver disease and hepatocellular carcinoma. She is trying to understand the molecular/cellular process on how RISC complex genes and protein are regulated when treated with many dietary natural products. Here, Varsha talks about her work titled “Withaferin A Acts as a Novel Regulator of Liver X Receptor-a in HCC” published as first author in Front Oncol 2021.