Impact of mAb Aggregation on its Biological Activity

Dr. Rozaleen Dash’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Dash completed her PhD in Biochemistry from All India Institute of Medical Sciences, New Delhi then, she joined as Scientist- B at Maulana Azad Medical College, New Delhi. Currently, she is doing Post-Doc as a ICMR-RA fellow in the Professor Anurag S Rathore Lab, Department of Chemical Engineering, Indian Institute of Technology Delhi, India. She has expertise in Functional Characterization of biotherapeutics, Comparability of Biosimilars and Drug immunogenicity. Here, she talks about her co-first author research article titled “Impact of mAb Aggregation on Its Biological Activity: Rituximab as a Case Study” published in the Journal of Pharmaceutical Sciences (2020).

Time-restricted feeding prevents breast cancer

Dr. Manasi Das did her Master in Life Sciences from Sambalpur University, Odisha, India. After that, she did her Ph.D. from the Institute of Life Sciences, Bhubaneswar, Odisha, India, under the supervision of Dr. Sanjeeb Kumar Sahoo, where she studied on Nanodrug delivery for breast cancer therapy. Presently, she is Postdoctoral Fellow in the Department of Medicine, University of California, San Diego, USA. Her research focuses on understanding the role of time-restricted feeding/eating intervention in breast cancer. Here, Manasi and Deepak talks about their work titled “Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models” published in Nature communications.

Bio Patrika interviews Dr. Das on his thoughts about “how ERK mediated phosphorylation regulate oocyte numbers”

Dr. Debabrata Das’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Das completed his Ph.D. as a DST-INSPIRE-fellow in the Cellular and Molecular Endocrinology Laboratory of Dr. Sudipta Maitra at the Department of Zoology, Visva-Bharati University, Santiniketan, India. His Ph.D. work was focused on the role of insulin-signaling pathway in regulating female reproduction using zebrafish as model organism. After his Ph.D., He joined the Arur Laboratory at the University of Texas MD Anderson Cancer Center in 2017. Currently, he is an Odyssey post-doctoral fellow. Here using C. elegans germline, he is working on the downstream substrates of RAS/ERK signaling pathway in regulating female fertility with special emphasis on meiosis I, as well as their role in cancer progression. Here, Debabrata talks about his PhD work titled “ERK phosphorylates chromosomal axis component HORMA domain protein HTP-1 to regulate oocyte numbers” published as a first author in Science Advances (2020).

Bio Patrika interviews Dr. Sridhar on his thoughts about “Understanding fundamental design principles of a cellular load-bearing machine”

Dr. Shreyas Sridhar’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Here, Shreyas talks about his PhD work titled “Bridgin connects the outer kinetochore to centromeric chromatin” published as first author in Nature Communications (2021).

Bio Patrika interviews Dr. George on his thoughts about “the application of innovative technology sgRNA-Click combined with CRISPR-dCas9”

Dr. Jerrin Thomas George’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. George completed integrated MS-PhD from the IISER Pune. He pursued his doctoral research in the group of Prof. Seergazhi G. Srivastan on developing chemo-enzymatic platforms to functionalize RNA with biophysical probes using template dependent and independent polymerases. He then had a short stay as a research associate at JNCASR, Bangalore in the group of Dr. Sarit S. Agasti and now plans to join Columbia University, New York as a postdoctoral research scientist. His research interest is in the broad area of chemical biology, and molecular biophysics. For his future carrier, he is interested in deciphering the molecular mechanism of novel gene editing tools using various biophysical techniques. Jerrin published part of his PhD work titled “Terminal uridylyl transferase mediated site-directed access to clickable chromatin employing CRISPR-dCas9” as first author in Journal of the American Chemical Society (2020).

Bio Patrika interviews Dr. Joshi on her thoughts about “Orthogonal tools for analytical biosimilarity assessment of biotherapeutics”

Dr. Srishti Joshi’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Joshi completed her PhD in Molecular Biology and Biochemistry from Massey University, NZ in 2015. After a brief Post Doc experience at the Systems Biology lab at Korea University, she joined DBT-COE-CBT (IIT-Delhi) in 2017 an Institute Post Doctoral Fellow in the lab of Prof. Anurag Rathore at the Centre of Excellence, Biopharmaceutical Technology (DBT-COE-CBT), Indian Institute of Technology, Delhi. She has been learning and exploring the domain of Analytics in Biotherapeutics, since. She published papers titled “An application of Nano Differential Scanning Fluorimetry for Higher Order Structure assessment between mAb originator and biosimilars: Trastuzumab and Rituximab as case studies” and “Monitoring size and oligomeric-state distribution of therapeutic mAbs by NMR and DLS: Trastuzumab as a case study” as first author in Journal of Pharmaceutical and Biomedical Analysis (2020).

Bio Patrika interviews Dr. Gadadhar on his thoughts about “finding novel mechanism behind male infertility”

Dr. Sudarshan Gadadhar’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Gadadhar is currently Senior postdoctoral research fellow in the lab of Prof. Carsten Janke at Institut Curie, PSL Research University, Department of Genome integrity, RNA and Cancer CNRS, France. Sudharshan published a paper titled “Tubulin glycylation controls axonemal dynein activity, flagellar beat and male fertility” as a first author in Science journal (2021).

Bio Patrika interviews Dr. Jagilinki on his thoughts about “In vivo biogenesis of a de novo designed iron-sulfur protein”

Dr. Bhanu Prakash Jagilinki’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Jagilinki is currently a Postdoctoral researcher under the guidance of Prof. Vikas Nanda and Prof. Paul Falkowski at Rutgers University, NJ, USA. Bhanu published a paper titled “In vivo biogenesis of a de novo designed iron-sulfur protein” as a first author in ACS Synthetic Biology (2020).

Bio Patrika interviews Dr. Kothiwal on his thoughts about “the role of cohesin complex in subtelomeric gene silencing and cell wall maintenance”

Dr. Deepash Kothiwal’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Kothiwal completed his PhD with Prof. Shikha Laloraya at the Dept. of Biochemistry, Indian Institute of Science Bangalore, India. The main focus of his doctoral study was to investigate the role of cohesin in subtelomeric silencing and organization. Currently he is a postdoctoral research fellow in the lab of Dr. Stephen Buratowski at the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, USA. His research interest include regulation of gene expression. Deepash published his PhD research findings as first author in two articles: “A SIR-independent role for cohesin in subtelomeric silencing and organization” published in Proceedings of the National Academy of Sciences of the United States of America (2019) and “Cohesin dysfunction results in cell wall defects in budding yeast” published in Genetics (2020).