TGR63 as a potential drug candidate for the treatment of Alzheimer’s Disease

Dr. Sourav Samanta’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. The author, Dr. Sourav Samanta, was born on May 1st, 1991, at Natibpur, West Bengal, India. After his initial schooling at Natibpur Bhudeb Vidyalaya, he obtained his Bachelor’s degree in Chemistry in 2013 from Bangabasi College under Calcutta University, India. He obtained his Master Degree in Chemistry in 2015 from the Department of Chemistry, Indian Institute of Technology Guwahati (IIT Guwahati), Assam, India. He joined the New Chemistry Unit (NCU), Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India, for the PhD program in August 2015 under the guidance of Prof. T. Govindaraju. He received his Doctor of Philosophy (PhD) degree in Chemistry from JNCASR in February 2021. Currently, he is appointed as a postdoctoral research associate (PRA) under the supervision of Prof. T. Govindaraju at JNCASR. Here, Sourav talks his first author wort titled ‘Naphthalene Monoimide Derivative Ameliorates Amyloid Burden and Cognitive Decline in a Transgenic Mouse Model of Alzheimer’s Disease’ publishd in Adv Therap (2021).

Women in science: I am a woman, a wife, a mother, and a scientist!

Dr. Manveen K Sethi serves as Instructor of Biochemistry at the Boston University School of Medicine, USA. She did her Ph.D. at Macquarie University (MQ), Australia, under the primary supervision of Dr. Morten Thaysen-Andersen,where she utilized mass spectrometry proteomics and glycomics analysis to understand underlying molecular mechanisms in colorectal cancer . After her Ph.D., she joined Boston University School of Medicine (BUSM), USA, as a postdoctoral associate under Prof. Joseph Zaia, where she is currently employed in a research faculty-track position of Instructor. Her research work involves identifying and characterizing biomolecules such as proteins and glycans using mass spectrometry techniques and utilizing this information to understand biomolecular deregulation in human diseases, such as cancer and Alzheimer’s disease. Recently, she received a Bright Focus Foundation fellowship award to investigate extracellular matrix changes in Alzheimer’s disease.

Bio Patrika interviews Dr. Sethi on her thoughts about “Serial in-solution digestion protocol for mass spectrometry-based glycomics and proteomics analysis”

Dr. Manveen K Sethi’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Sethi serves as Instructor of Biochemistry at the Boston University School of Medicine, USA. She did her Ph.D. at Macquarie University (MQ), Australia, under the primary supervision of Dr. Morten Thaysen-Andersen, an internationally recognized researcher in Glycobiology. During her Ph.D., she forayed into colorectal cancer (CRC) research. After her Ph.D., she was offered a postdoctoral research fellowship at Boston University School of Medicine (BUSM), USA, under Prof. Joseph Zaia, an internationally-acclaimed leader in mass spectrometry (MS) and Glycoscience, where she is currently employed in a research faculty-track position of Instructor. Her research work involves identifying and characterizing biomolecules such as proteins and glycans using mass spectrometry techniques and utilizing this information to understand biomolecular deregulation in human diseases, such as cancer and Alzheimer’s disease. Here, Manveen talks about her work titled “Serial in-solution digestion protocol for mass spectrometry-based glycomics and proteomics analysis” published as a first author in Molecular Omics (2020).

Bio Patrika interviews Dr. Kedia on his thoughts about “Role of synaptic nanoscale organization in Alzheimer’s disease”

Dr. Shekhar Kedia’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Kedia is Postdoctoral fellow in the lab of Dr. Deepak Nair at Centre for Neuroscience, Indian Institute of Science (IISc), Bangalore, India. Dr. Kedia published a paper titled “Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer’s disease” in iScience (2020) as a first author.

Bio Patrika interviews Dr. Guha on his thoughts about “the role of tau modifications in mitochondrial dysfunction and Alzheimer’s disease”

Dr. Sanjib Guha’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Guha is currently a Postdoctoral research associate in the Department of Anesthesiology & Perioperative Medicine, University of Rochester Medical Center, Rochester, USA. He published a paper titled “Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model” as the first author in Molecular Neurodegeneration journal (2020). Dr. Guha also published a review article titled “The crosstalk between pathological tau phosphorylation and mitochondrial dysfunction as a key to understanding and treating Alzheimer’s disease” in Molecular Neurobiology journal (2020) as corresponding author.