Novel drugs block TRPV6 calcium channel like a natural plug

Rajesh Bhardwaj’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Trained in Bioinformatics at the University of Hyderabad, Dr. Rajesh Bhardwaj, who hails from Haryana, switched gears to Biochemistry and conducted his doctoral research on physical coupling mechanisms of endoplasmic reticulum and plasma membrane at Heidelberg University, Germany. He is currently working as a senior research associate at the University of Bern, Switzerland. His work combines molecular biology and computational structural biology techniques with state-of-the-art high-throughput screening and electrophysiology. The goal is to understand different aspects of store-operated, calcium release-activated calcium (CRAC) channels and epithelial calcium channel TRPV6, such as the mechanisms that regulate their activation and inactivation, regulation by oxidative stress, and modulation by chemical compounds. Here, Dr. Rajesh talks about how ‘novel drugs block TRPV6 calcium channel like a natural plug’ and discuss his first author research article titled “Inactivation-mimicking block of the epithelial calcium channel TRPV6” published in Sci Adv. (2020).

Bio Patrika interviews Ms. Sharma on her thoughts about “the modulation of flight and feeding behaviours of fruit flies”

Ms. Anamika Sharma’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Ms. Sharma is a PhD student in the lab of Prof. Gaiti Hasan at National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore. Anamika published a paper entitled “Modulation of flight and feeding behaviours requires presynaptic IP3Rs in dopaminergic neurons” as a first author in eLife journal (2020).