Calcium sensor STIM1 regulates gene expression and synaptic connectivity of Purkinje neurons

Sreeja Kumari Dhanya’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dhanya is a Ph.D. student working under the guidance of Prof. Gaiti Hasan in National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore. She completed her master’s in Medical Biotechnology from Manipal School of Life Sciences (MSLS) at Manipal Academy of Higher Education (MAHE), Manipal. Her doctoral research focuses on understanding the role of STIM1 (Stromal Interaction Molecule), a calcium sensor molecule present in the endoplasmic reticulum (ER) and investigating its role in regulating gene expression, excitability and synaptic connectivity in mouse Purkinje neurons (PNs). Her research has significantly contributed to uncovering novel aspects of intracellular calcium signaling in regulating neuronal functions and physiology in mammalian system. Dhanya, as her long-term goal, envisages exploring signaling mechanisms involved in various neurodegenerative disorders and identifying novel therapeutic insights. Here, Dhanya talks about her work on ‘Purkinje Neurons with Loss of STIM1 Exhibit Age-Dependent Changes in Gene Expression and Synaptic Components’ published in Journal of Neuroscience.

Bio Patrika interviews Dr. Sethi on her thoughts about “Serial in-solution digestion protocol for mass spectrometry-based glycomics and proteomics analysis”

Dr. Manveen K Sethi’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Sethi serves as Instructor of Biochemistry at the Boston University School of Medicine, USA. She did her Ph.D. at Macquarie University (MQ), Australia, under the primary supervision of Dr. Morten Thaysen-Andersen, an internationally recognized researcher in Glycobiology. During her Ph.D., she forayed into colorectal cancer (CRC) research. After her Ph.D., she was offered a postdoctoral research fellowship at Boston University School of Medicine (BUSM), USA, under Prof. Joseph Zaia, an internationally-acclaimed leader in mass spectrometry (MS) and Glycoscience, where she is currently employed in a research faculty-track position of Instructor. Her research work involves identifying and characterizing biomolecules such as proteins and glycans using mass spectrometry techniques and utilizing this information to understand biomolecular deregulation in human diseases, such as cancer and Alzheimer’s disease. Here, Manveen talks about her work titled “Serial in-solution digestion protocol for mass spectrometry-based glycomics and proteomics analysis” published as a first author in Molecular Omics (2020).

Bio Patrika interviews Dr. Kedia on his thoughts about “Role of synaptic nanoscale organization in Alzheimer’s disease”

Dr. Shekhar Kedia’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Kedia is Postdoctoral fellow in the lab of Dr. Deepak Nair at Centre for Neuroscience, Indian Institute of Science (IISc), Bangalore, India. Dr. Kedia published a paper titled “Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer’s disease” in iScience (2020) as a first author.

Bio Patrika interviews Dr. Guha on his thoughts about “the role of tau modifications in mitochondrial dysfunction and Alzheimer’s disease”

Dr. Sanjib Guha’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Guha is currently a Postdoctoral research associate in the Department of Anesthesiology & Perioperative Medicine, University of Rochester Medical Center, Rochester, USA. He published a paper titled “Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model” as the first author in Molecular Neurodegeneration journal (2020). Dr. Guha also published a review article titled “The crosstalk between pathological tau phosphorylation and mitochondrial dysfunction as a key to understanding and treating Alzheimer’s disease” in Molecular Neurobiology journal (2020) as corresponding author.