Biological Condensates learning videos

Biological condensates

Biological condensates or bio-condensates or protein droplets are membrane-less organelles formed as a result of proteins undergoing liquid-liquid phase separation or demixing. This is an important phenomenon which was recently discovered and is now not only considered critical for normal biological functions but also linked to pathological conditions like neurodegenerative diseases and cancer. Considering the importance of this natural phenomenon, I have compiled a list of sources providing videos or movies of the formation of biological condensates or describing this phenomenon in detail:

Video Resources on Biomolecular Condensates

1. Three-part video lecture series by Prof. Cliff Brangwynne (available on iBiology and YouTube):
   • Part 1: Liquid Phase Separation in Living Cells
   • Part 2: Multiphase Liquid Behavior of the Nucleus
   • Part 3: Using Light to Study and Control Intracellular Phase Behavior
2. Science Sketches – A project started by Prof. Anthony Hyman’s Lab. These are short two-minute videos explaining research topics including protein phase separation. Also available on YouTube channel and YouTube playlist.
3. Four-part lecture series titled Cellular Organization of Complex Cell Structures by Prof. Anthony Hyman (Watch here). The last part covers P granules.
4. Video abstract of the Cell article A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation – by Prof. Anthony Hyman and Prof. Simon Alberti groups.
5. Video by Dr. Ashok Deniz – Demonstrates the role of RNA in forming membrane-less organelles.
6. New tools to study phase separation – Video covering tools and findings from Dr. Cliff Brangwynne’s group.
7. Liquid demixing of intrinsically disordered proteins – YouTube video from Dr. Jiri Lukas’s group at the University of Copenhagen.
8. Phase condensation in transcription – Richard Young’s lab, Whitehead Institute.
9. Lysozyme-PEG liquid-liquid phase separation – Franden lab shows phase separation using Phase Chip.
10. Photo-activatable FUSn droplets in U2OS cells – Video 1
    Second video
11. Liquid Phase Separation and Cancer – Prof. Karla Neugebauer, Yale University.
12. SPOP mutations and LLPS disruption in cancer – Dr. Tanja Mittag, St. Jude Children’s Research Hospital.
13. How biomolecular condensates form – Video from Rosen Lab.
14. Phase transitions in biology – Dr. Avinash Patel (Dewpoint) at CLINAM 2016.
15. Conformational heterogeneity in LLPS – Dr. Hue Sun Chan, University of Toronto.
16. Spider silk droplet LLPS – Videos from Dr. Pezhman Mohammadi (Aalto University).
17. How hard are these protein droplets? – Laser tweezers video from Dr. Priya R. Banerjee, University at Buffalo.
18. Cajal body in genome and transcriptome – Video abstract to BioEssays article by Dr. Gordon Hager and Dr. Miroslav Dundr.
19. Cajal Body and snRNP biogenesis – Video lecture by Dr. David Stanek (Czech Academy of Sciences).
20. snRNA localization via microinjection – JOVE video from Dr. David Stanek.
21. P-bodies and mRNA cycle – Prof. Roy Parker, University of Colorado Boulder (also on iBiology).

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