Hidden Language of Proteins!
New study published in Science reveals that protein sequences contain hidden codes that guide them to specific subcellular compartments, ensuring precise organization within cells. With ~10 billion protein molecules needing to be correctly distributed, this discovery reshapes our understanding of protein localization!
🚀 Key Highlights:
🔹 Proteins with shared functions share common amino acid sequence codes that direct them to the same compartments.
🔹 ProtGPS, a protein language model, was developed to accurately predict protein compartment localization.
🔹 ProtGPS was used to design novel proteins that selectively assemble in the nucleolus.
🔹 The model identified disease-causing mutations that alter these compartmentalization codes, potentially leading to pathological mislocalization.
🧩 Beyond the Folding Code: This study suggests that protein sequences not only encode folding information but also contain a hidden localization code, governing their precise subcellular distribution.
📖 Read more on Hidden Language of Proteins: Science
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