Withaferin A as a potent regulator of hepatocellular carcinoma

Varsha D. Shiragannavar’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Varsha is currently a second year Ph.D. student working in the lab of Dr. Prasanna K. Santhekadur at Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory, Department of Biochemistry, JSS Medical College, JSS AHER, Mysuru. Her doctoral studies is primarily focused on investigating the role of RNA-induced silencing complex and associated proteins in the progression of non-alcoholic fatty liver disease and hepatocellular carcinoma. She is trying to understand the molecular/cellular process on how RISC complex genes and protein are regulated when treated with many dietary natural products. Here, Varsha talks about her work titled “Withaferin A Acts as a Novel Regulator of Liver X Receptor-a in HCC” published as first author in Front Oncol 2021.

Time-restricted feeding prevents breast cancer

Dr. Manasi Das did her Master in Life Sciences from Sambalpur University, Odisha, India. After that, she did her Ph.D. from the Institute of Life Sciences, Bhubaneswar, Odisha, India, under the supervision of Dr. Sanjeeb Kumar Sahoo, where she studied on Nanodrug delivery for breast cancer therapy. Presently, she is Postdoctoral Fellow in the Department of Medicine, University of California, San Diego, USA. Her research focuses on understanding the role of time-restricted feeding/eating intervention in breast cancer. Here, Manasi and Deepak talks about their work titled “Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models” published in Nature communications.

Job opening in CyGenica

If you wish to work in a cuttingedge biotech startup helping solve serious healthcare challenges, working on a next generation drugdelivery system, and technology platforms as Crisper Cas9, that will help improve the lives of cancer patients, contribute to translating RnD to the clinic, work in the wonderful campus of Venture Center (Official Account) and be part of a young, dynamic, and vibrant team at CyGenica (with operations in India and Ireland) led by Nusrat Jahan Sanghamitra, then do apply for the positions advertised.

Impact of Nanotechnology in Rural Area for Health and Safety: Farmers in Natural Agroengineering

For 20 years, Brij Lal Meena has been trying to produce better and healthy food using fruit farming methodologies. He has noticed non-scientific and toxic chemical methodologies for farming and agriculture that cause various human health issues. Additionally, he has seen a rapid growth of cancer in rural areas “especially in North India.” Therefore, he decided to work for healthy food production without using carcinogenic chemicals. Recently, Brij Lal Meena started working with Dr. Rajendra Prasad, who is a Nanomedicine Investigator at Prof. Rohit Srivastava’s NanoBios Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai Powai, India. Brij Lal Meena is an agroengineer farmer who belongs to a remote village named Jirota, Karauli in Rajasthan. He has noticed various cancer cases in rural areas suffering from the high cost of treatment and lack of knowledge for early-stage diagnosis and treatment causing immense pressures on cancer patients that made him work for toxic chemical-free fruit farming “food production” as an Agroengineer. He has approached Dr. Rajendra to utilize and learn nanomedicine concepts for a better quality of fruit production without using toxic chemicals.

Bio Patrika interviews Dr. Sreekanth and Mr. Kar on their thoughts about “bile based nanomicelles as delivery platform for anticancer agents”

Dr. Vedagopuram Sreekanth and Mr. Animesh Kar’s joint interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Work described here is done in the lab of Dr. Avinash Bajaj at Regional Centre for Biotechnology, Faridabad, Dr. Ujjaini Dasgupta at Amity University, Haryana, Dr. Sagar Sengupta and Dr. Arnab Mukhopadhyay at National Institute of Immunology, New Delhi. Currently Dr. Sreekanth is a Postdoctoral research fellow at Brigham and Women’s Hospital, Harvard Medical School, USA and Mr. Kar is a Ph.D. Scholar at Regional Centre for Biotechnology, Faridabad, India. They published a paper titled “Bile Acid Tethered Docetaxel‐based Nanomicelles Mitigate Tumor Progression through Epigenetic Changes” as joint first authors in Angew. Chem. Int. Ed. journal (2020).

Bio Patrika interviews Dr. Prasad on his thoughts about “Safe nanotheranostics: Clinically relevant nano-platform for solid tumor imaging and near‐infrared light mediated cancer therapy”

Dr. Rajendra Prasad’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Dr. Prasad is currently working as an Institute Postdoctoral Fellow and Nanomedicine Investigator in the lab of Prof. Rohit Srivastava at the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai Powai, India. Dr. Prasad has published a paper entitled “Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy” as a first author in Communications Biology (2020) published by Nature and has filed an Indian Patent entitled “Fluorescent gold nanorods and method of preparation thereof” that is granted recently IN350710.

Bio Patrika interviews Mrs. Singh on her thoughts about “miRNA replacement based cancer therapies”

Mrs. Anukriti Singh’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Mrs. Singh is currently a PhD student in the lab of Prof. Bushra Ateeq at the department of Biological Sciences & Bioengineering, Indian Institute of Technology, Kanpur. She published a paper titled “Targeting AGTR1/NF-κB/CXCR4 axis by miR-155 attenuates oncogenesis in glioblastoma” as a first author in Neoplasia journal (2020).

Bio Patrika interviews Mr. Duddu on his thoughts about “regulation of cell fate decisions”

Mr. Atchuta Srinivas Duddu’s interview with Bio Patrika hosting “Vigyan Patrika”, a series of author interviews. Mr. Duddu is currently a PhD student in the Cancer Systems Biology Laboratory of Dr. Mohit Kumar Jolly at the Centre for BioSystems Science and Engineering, Indian Institute of Science Bangalore. Mr. Duddu completed his M. S. (ECE) from University of California San Diego and B. Tech. (Instrumentation) from IIT Kharagpur. He published a paper titled “Multi-stability in cellular differentiation enabled by a network of three mutually repressing master regulators” as the first author in Journal of the Royal Society Interface (2020).