spot_imgspot_img

Biotin as a Shield Against Manganese-Induced Parkinsonism!

🔬 Latest study published in Science Signaling uncovers how biotin (Vitamin B7) mitigates manganese-induced neurotoxicity, a key environmental factor linked to Parkinson’s disease (PD).

🚀 Key Findings:
Drosophila Model of Mn Toxicity: Researchers developed a fruit fly model that mimicked PD-like symptoms, including motor deficits, neuronal loss, and mitochondrial dysfunction.
Biotin Deficiency Worsens Neurotoxicity: Flies with impaired biotin metabolism showed exacerbated PD symptoms upon manganese exposure.
Biotin Supplementation Protects Against Mn Toxicity: Adding biotin to the diet ameliorated neurodegeneration and mitochondrial damage in flies and three standard PD fly models.
Human Relevance: Supplementing human dopaminergic neurons (derived from induced pluripotent stem cells) with biotin prevented Mn-induced neuronal loss and mitochondrial dysfunction.
PD Patients Show Altered Biotin Metabolism: Postmortem analysis revealed increased biotin transporter levels in the substantia nigra of PD patients, suggesting a potential metabolic adaptation.

🌟 Why It Matters?
🔹 Chronic manganese exposure is a recognized environmental risk factor for PD.
🔹 Biotin supplementation may serve as a preventive strategy for at-risk individuals.
🔹 The study paves the way for potential nutritional interventions to combat neurodegeneration.

📖 Read the full study: Science Signaling

💡 Could biotin be the key to protecting neurons from Mn-induced damage? 🤔 Let’s discuss! 👇

Get in Touch

LEAVE A REPLY

Please enter your comment!
Please enter your name here

spot_imgspot_img

Related Articles

spot_img

Get in Touch

588FansLike
520FollowersFollow
4,100FollowersFollow
780SubscribersSubscribe

Latest Posts